| Character | Cast 1 | Cast 2 |
|---|---|---|
| JACK KELLY | Darien | Drew |
| CRUTCHIE | Marshall | Micah |
| DAVEY | Michael | Payten |
| LES | Adam | Braiden |
| RACE | Amy | Adi |
| ALBERT | Jessica | Kristen |
| SPECS | Sophie | Annie |
| HENRY | Kinley | Emily |
| FINCH | Noël | Lauren |
| ROMEO | Micah | Marshall |
| ELMER | Kaitlyn | Spencer |
| SCABS | Atley, Annie, Lauren | Kinley, Mica, Jessica |
| SPOT COLON | Kristen | Sophie |
| KATHERINE | Mikiah | Kristin |
| DARCY | Emily | Amy |
| BILL | Payten | Noel |
| WIESEL | Nate | Cade |
| MORRIS DELANCEY | Payten | Amy |
| OSCAR DELANCEY | Emily | Noel |
| PULITZER | Drew | Michael |
| SEITZ | Lauren | Mica |
| BUNSEN | Atley | Kinley |
| HANNAH | Annie | Jessica |
| NUNZIO | Chloe | Noah |
| GUARD | Ruthie | Noah |
| POLICE OFFICER | Noah | Ruthie |
| SNYDER | Spencer | Kaitlyn |
| MEDDA | Adi | Mya |
| BOWERY BEAUTIES | Atley, Mica, Annie, Lauren, Ruthie, Sophie, Kinley, Bianca, Kristin, Kristen, Noël | Atley, Mica, Annie, Lauren, Ruthie, Sophie, Kinley, Kaitlyn, Mikiah, Jessica, Emily |
| STAGE MANAGER | Mya | Nate |
| NUNS | Adi, Bianca, Lauren | Jessica, Amy, Sophie |
| MR. JACOBI | Nate | Matthias |
| MAYOR | Ruthie | Nate |
| TEDDY ROOSEVELT | Nate | Darien |
| WOMAN | Annie | Jessica |
| BUTTONS | Chloe | Chloe |
| MUSH | Cade | Bethany |
| TOMMY BOY | Bethany | Bianca |
| JOJO | Matthias | Frits |
| CAMARA MAN | Zac | Ben |
| GOONS | Zac, Ben, Bethany, Drew | |
| NEWSIES ENSEMBLE | Zac, Frits, Braiden, Ruthie, Mya, Kristen, Bianca, Mica, Ben, Spencer, Noah | Nate, Ben, Matthias, Ruthie, Mya, Mikiah, Kaitlyn, Darien, Atley, Zac, Adam |